Trials of a new weight loss drug are nearing completion with (according to the company responsible) some pretty promising results.

Zafgen the manufacturers of the consumer friendly named ZGN-433 ran a double-blind placebo-controlled study of 24 obese women and found that each had lost an average of 2lbs per week over a 1 month period.

The women also claimed to feel less hungry and less likely to snack between meals as the trial went on.

The New Scientist described the results as ‘stunning’ considering that the women continued to eat normally and were not given exercise advice or any special instructions.

“1 in 4 Britons are overweight”

The drug is set to target 25% of the adult British population – 1 in 4 are now adjudged to be very over weight or obese.

It is not in great detail how the drug is supposed to weight apart from it breaks down fat – previous research has suggested the more overweight you become the harder it is for the body to shift it because the body becomes ‘programmed’ to make and store more fat.

Scientists at Zafgen believe ZGN-433 blocks an enzyme, which prevents several genes from functioning properly. This means they no longer activate other genes that stop insulin from working effectively.

Is Zafgen ZGN-433 Worth Waiting For

The drug will most likely be available via the prescription only route, meaning it will not be available to buy over the counter restricting a large proportion of the UK population.

It is hard to get too excited about Zafgen when there are several products that exist right now and have a proven level of working success.

The non prescription marketplace is currently thriving with some products that offer a better and safer alternative to GP prescribed medication.

Read Best Diet Pills To Buy 2011

___________________________________________

A new diet drug is the final stages of development and should be available via prescription in 2011.

Tesofensine is the name of the drug developed by Neurosearch, an experimental drug company and will possibly be rebranded commercially at a later date.

Tesofensine is said to offer twice the weight loss of competing prescribed weight loss drugs – but at what cost.

Prescribed diet drugs have a pretty poor record when the safety element is scrutinised. Both Reductil and Acomplia have been subject to bad press and some rather nasty side effects over the last few years with both being subjected to calls fro a withdrawal from the marketplace.

How Does Tesofensine Work

Tesofensine effects the brain, there are three different regions that the drug targets and increases the transmission of three neurotransmitters, namely,  dopamine, noroadreneline and seratonin. All the neurotransmitters act to reduce appetite and increase the metabolism.

Dopamine acts to send the brain messages about the pleasure derived from food, while noroadreneline and serotonin increase metabolism and reduce appetite.

Tesofensine Side Effects

So far clinical trials have thrown a few side effect issue that need to be address prior to release. The most common side effects were dry mouth, insomnia and intestinal problems.

When Will Testofensine Be Available

There is no confirmed date yet.

Can I Buy Tesofensine Over The Counter

it is highly unlikely that it will be available without prescription.

Is Tesofensine Worth The Wait

It is important to remember that weight loss drugs are exactly that, DRUGS and so do not come without complication and a risk to health.

With the advancement of natural based diet pills it could be argued that prescribed drugs are not as an attractive proposition as they once where.

Alternative Diet Pills

One of the most effective, powerful and yet safe product currently available without prescription is Phen375

Phen375 is synthetically manufactured formula produced in FDA pharmaceutical registered laboratories using pharmaceutical grade substances including: a combination of cyclic AMP enzyme boosters such as 1,3-Dimethypentylamine Hydrochloride, 1,3,7-Trimethylxanthine, and a Sympathomimetic Amine, Dehydroepiandrosterone and l-carnitine.

More about Phen375

_________________________________________________________

Can I buy Phentermine in the UK is one of the most frequent search terms typed in a search engine (Google, Yahoo etc).

There are thousands of people daily trying to order Phentermine from the internet despite the fact that Phentermine is a prescription only drug and cannot be purchased legally in Britain from either the high street or any UK based website or webstore.

There is a fascination surrounding Phentermine because of its reputation as a strong appetite suppressant and fat burning potential.

Phentermine has a less than glorious past with many side effects associated with the drug.

This fascination often leads to purchases being from the internet from website outside of the UK.

It is highly advised that you do not attempt to buy Phentermine from any website that offers no matter how tempting.

A recent BBC watchdog style documentary highlighted this fact.

Watch BBC media coverage – Counterfeit Diet Pills

Phentermine Substitutes

There are however several Phentermine substitues than can be purchased freely without restriction that can offer the potency of the drug while remaining within the law – and more importantly negating the side effect issue.

Possibly the best Phentermine substitute we have reviewed is Phen375

Phen375 is synthetically created formula produced in FDA pharmaceutical registered laboratories using pharmaceutical grade ingredients including: a combination of cyclic AMP enzyme boosters such as 1,3-Dimethypentylamine Hydrochloride, 1,3,7-Trimethylxanthine, and a Sympathomimetic Amine, Dehydroepiandrosterone and l-carnitine.

Read more about Phen375

____________________________________________________

Phentermine is a prescription only diet pill that is not available to buy over the counter or legally from the internet without GP consultation.

It is a powerful weight loss drug and made from chemically produced substances – it is a stimulant that is similar to an amphetamine or speed. Phentermine suppresses appetite by interfering with the central nervous system.

Phentermine has a long history and has remained almost unchanged in formula. Some fifty years on and it has evolved laterally into the commercial products we have today.

Arguably the best example of a commercial Phentermine substitute is Phen375 –  it is currently available to buy direct without a prescription, but for how long?

Buy Phen375 Direct

Phen375 Powerful Fat Burner And Appetite Suppressant

Phen375 Is a pure synthetic Phentermine substitute that offers the appetite suppressing benefits (plus a fat burning ingredient) of the drug but more naturally produced.

It is manufactured in a FDA regulated lab using premium quality pharmaceutical grade ingredients that are clinically proven to provide you with the highest fat burning and appetite suppressing capability possible.

Phen375 is available to buy without prescription and manufactured in accordance with all necessary guidelines.

If you are not eligible for a course of prescription diet pills or want to sample the benefits of Phentermine without the potential side effects, Phen375 is ideal.

How Phen375 Can Aid Weight Loss

• Suppresses appetite greatly reduce the need and want to snack between meals. Dramatically reduces your daily calorie intake by helping you to feel fuller sooner during a meal.
• Increases the metabolism, and fat burning ability by your body
• Increases energy levels and improves stamina levels
• Typically users can experience an average fat loss of around 3lbs to 5lbs per week

Phen375 Success Stories

The oficial website displays a sample of success stories and testimonials – the testimonials given are from real individuals and are legitimate and believable.

Read Real Life Phen375 Success Stories

Phen375 Ingredients

Phen375 is a combination of cyclic AMP enzyme boosters such as 1,3-Dimethypentylamine Hydrochloride, 1,3,7-Trimethylxanthine, and a Sympathomimetic Amine, Dehydroepiandrosterone and l-carnitine

Phen375 Side Effects And Cautionary Measures

Every diet pill, prescription, herbal or otherwise has the potential to cause a side effect. Phen375 is highly unlikely to cause any adverse reaction if taken as recommended.

Does Phen375 Work

Phen375 offers a safer alternative to prescription grade drugs, it is guaranteed for 45 days – if you feel you are not benefiting from Phen375 you are entitled to your money back (within 45 days)

Where To Buy Phen375 UK

Phen375 is only available to buy from the official website. Orders can be placed either online, by post or via the telephone.

The company behind Phen375, RDK Holdings, display multiple ways of contact – something that a large majority of competitive products fail to do!

Visit Phen375 website

____________________________________________________

Now available in Australia – Phen375 Australia

For the second time in just under a year an anti obesity diet pill has been banned and withdrawn from pharmacists shelves.

In the early spring Acomplia was removed amid possible suicide risk and other associated mental problems. Now Reductil has be banned due to links with potential risk of heart attacks and strokes.

The European Medicines Agency acted swiftly and the ban will take place with immediate effect – GP’s are currently contacting patients who are under prescription are advising them stop.

What Is Reductil

Reductil uses the active ingredient Sibutramine, an appetite suppressant that works by fooling the brain into telling the stomach that it is full.

It is not available to buy in the high street or legitimately online via the web.

Alternatives To Reductil

Appetite suppressants are extremely effective in the weight loss process – natural appetite suppressants exits that do not present the potentially harmful side effects that chemically produced drugs do.

More about Natural Appetite Suppressants

________________________________________________

Duromine is the brand name for a prescription only diet drug that suppresses appetite.

Duromine is prescribed by GP’s to morbidly obese patients that are urgent need of a weight reduction and have a particularly high BMI (Body Mass Index) – usually 28 or above.

The main ingredient is Phentermine – more about Phentermine

Duromine is only one of a few diet drugs that have the approval of the FDA (Food & Drugs Administration) – but do carry a possible and quite significant risk to health.

For this reason it is highly advised to resist the temptation to buy Duromine from any source – only obtain GP consultation and subsequent prescription.

Duromine Ingredients

Phentermine is the active ingredient- it is combined with a resin to create slow release which prolongs the effect.

Other ingredients include.

• Phentermine
• Lactosevliquid paraffin
• Magnesium stearate
• Gelatin
• Titanium dioxide
• Carbon black

How Does Duromine Work

An appetite suppressant that can dramatically reduce daily calorie intake.

Hunger cravings and the need for snacking are reduced as the active chemical ingredient in Duromine effects the parts of the central nervous system.

Phentermine is chemically similar to amphetamine (more commonly known as speed) and increased energy levels are not uncommon amongst patients.

Duromine Side Effects

The active ingredients (Phentermine) can be responsible for several potential side effects some pretty nasty.

Phentermine is also highly addictive and users can develop a dependency.

Common side effects include:

• Restlessness
• Headache
• Insomnia
• High blood pressure
• Dysphoria
• Diarrhea, Constipation
• Breathing problems
• Chest pain

If the symptoms persist stop taking immediately and consult your GP.

Can I Buy Duromine From The Internet

The great thing about the web is that practically anything can be purchased – unfortunately this is also one of its worst traits.

Duromine and unbranded Phentermine are controlled substances and should not be purchased – although some unscrupulous websites supply diet drugs it is highly advised to refrain. Not only for the potential unsupervised taking of a diet drug but your chances of receiving a legitimate product are slim to put it mildly.

Alternatives To Duromine

Phen375 is the legal alternative to Phentermine. It has been coined Phentermine evolved.

Phen375 is produced in FDA approved facilities using premium grade ingredients.

Phen375 is a highly effective fat burner and appetite suppressant.

More about Phen375

______________________________________________

If you are considering using a diet pill there is one very big decision to make.

Should I use a prescribed or prescription diet pill or choose one of the over the counter products via the high street or from the web.

In reality though the decision is out of your hands – a prescribed diet pill does not really involve a choice, it is your GP or doctor that makes the choice if he or she considers your current health issue to be to such an extent that a drug is your best chance of reducing your weight.

A typical benchmark is your BMI (Body Mass Index) if you have a BMI of 30 or above you may stand a chance of being a prescription, any lower and you will have little chance.

Prescribed diet pills are chemically produced substances and classed as drugs – there is nothing natural about prescription diet pills.

If you are offered a prescription you will have to think about the possible side effects – prescribed slimming tablets significantly raise the possibility of causing side effects. Some are just a minor irritant but others can have more severe implications.

Commonly Prescribed Slimming Tablets

Typically there are only a handful of products that your GP is likely to prescribe should you qualify:

Xenical – a high strength fat blocker that uses the active ingredient Orlistat.

Xenical can block around a quarter of dietary fat food consumed but can cause side effects. Xenical is by far the most commonly prescribed slimming drug. More about Xenical

Other slimming drugs that are often prescribed are Reductil, Phentermine, Meridia and Bontril – these are appetite suppressants and dramatically reduce your want or need for food.

Just as with Xenical, prescription appetite suppressants can also cause a wide range of side effects. More about Appetite Suppressants

Can I Buy Prescription Diet Pills

One of the most frequently asked questions is “Can I buy prescription only diet pills over the counter or via the web?” This is where the the concept gets a bit cloudy.

Prescription diet pills should only be available via GP or doctor consultation, however the black market does exist.

It is highly advised to refrain from purcahsing any drug classed weight loss product from the web – at best the chances of recieving the legitimate “ordered” product are extremely low and at worst you will be unsupervised during your administration of the drug into your body.

So, if you are considering the use of a prescription diet pill – your first point of call should be with your GP!

Alternatives To Prescribed Diet Drugs

Non prescription or over the counter diet pills can be obtained without any recommendation or approval from your GP.

Over the counter or OTC diet pills are usually herbal based an present a much lower chance of experiencing a side effect.

The choices available in this market can be overwhelming.

If you are considering buying a non prescription diet pill – Read Herbal Diet Pills

Reductil is another commonly prescribed diet pill or diet drug – it is the brand name for the active ingredient Sibutramine.

Like most other prescription only diet pills, Reductil has been proven to be effective to tackle obesity but can also cause a few problems of its own.

Prescription only diet pills are not available to purchase either in the high street or from independent websites. Diet pills such as Reductil are very much chemical compounds (drugs) and so have to adhere to governmental legislation.

The most likely prescribed diet drug is Xenical. Read about Xenical

How Does Reductil Work

During the consumption of food our brain releases two chemicals; noradrenaline and serotonin. When these two naturally produced chemicals reach the required level we feel full and the need or want for food ceases.

After time our noradrenaline and serotonin levels normalise and reach a lower level where we feel like eating again – Reductil can stop the levels of these two chemicals reaching a lower point thus lengthening the time between the want or need for food.

In other words the active ingredient (Sibutramine) suppresses appetite and greatly reduces your daily calorie consumption.

Does Reductil Cause Side Effects

Although Sibutramine has been approved by the FDA (Food and Drugs Administration) as an anti obesity treatment there are several side effects that could result.

Common side effects include: nausea, upset stomach, dry mouth, increased heart rate, dizziness, headache, increased blood pressure, depression, and joint and muscle pain.

If you do experience any of the side effects detailed, cease taking and report any serious side effects to your doctor immediately.

How To Obtain Reductil

As mention previously all diet pills that are prescription only (or should be prescription only) can only be obtained via GP consultation.

Your GP or doctor may or may not prescribe – it will be largely dependent on your current BMI (Body Mass Index) and your GP’s stance of diet pill. Some GP’s prescribe and are in favour, others are not.

Natural Alternatives To Reductil

In April 2011 the MHRH (Medicine & Health Regulatory Authority) to comply with EU regulations has ruled that diet pills can only be supplied to a british consumer base if the product meets certain criteria. While hundreds of competing brands have and are disappearing Proactol Plus remains.

Proactol Plus is Legal, Effective  and Available without prescription

More about Proactol Plus

Phentermine is the term to describe the ingredient (Phentermine) and not a specific brand of slimming pill.

There appears to some confusion surrounding this powerful appetite suppressant – such as is it legal, it is a prescription drug or can I buy it over the counter.

So firstly, Phentermine is not an illegal slimming drug but it is a substance that is used as an active ingredient in some prescription only diet pills.

Phentermine is a stimulant that is similar to an amphetamine (speed). It is an appetite suppressant that affects the central nervous system by causing a feeling of satiety (fullness.)

Phentermine is aimed at people who are dangerously overweight or bordering on obese – not recommended for the causal dieter or for those who want to lose a few pounds for vanity reasons.

It was was first introduced in the late 1950′s – half a decade on and the aura of this drug still exists. In truth some of the naturally produced appetite suppressants using substances extracted from cactuses and seaweed offer a similar standard of weight loss effect while remaining virtually free from side effects.

_______________________________________________

***** New Product Update *****

Since this review was written a new Phentermine based product has been released.

Phen375 Is a pure synthetic Phentermine alternative that can mimic the effect of the prescription only drug without the potential for the side effects or addiction.

It is made in a FDA regulated lab using premium quality pharmaceutical grade ingredients that have been clinically proven to provide you with the highest fat burning and appetite suppressing capability possible.

It is available to buy without the need of a prescription via the manufacturers official website.

More about Phen 375

_______________________________________________

Organic products are widely available and are the sensible alternative

Is Phentermine By Prescription Only

It is drug class weight loss medication and should only be administered by a GP or health care professional – unfortunately Phentermine is widely available to buy on the internet at many worldwide online pharmacies – it is highly advised to resist the temptation.

Phentermine is also know under the following brand names: Adipex-P, Dapex, Fastin, Ionamin, Obe-Nix, Obephen, Obermine, Obestine-30, Parmine, Phentrol, T-Diet, Teramin, Unifast Unicelles, Wilpowr.

Phentermine Side Effects

On a scale of 1 to 10 with 10 being the worst – Phentermine scores a lofty 8 in side effects league. Do not consider taking Phentermine until you are well aware of the negative health implications.

Some of the side effects that have been associated are:

• A shortness of breath or breathing difficulties
• Weight gain, abdominal swelling
• Chest pain, fast or uneven heartbeat, feeling like you might pass out
• Mood swings, confusion or a state of unrest
• High blood pressure, with sever headache
• Blurred vision and hearing distortion
• Insomnia, difficulty sleeping or resting
• Diarrhea or constipation
• Hives or an itching sensation

Some users may experience an acute allergic reaction causing the lips, throat and air ways to restrict – if this occurs call the emergency services.

Is Phentermine Recommended

Phentermine is strong appetite suppressant – but the high risk of potentially dangerous side effects outweigh the benefits especially considering the natural world has several potent appetite suppressing product available that will not cause any of the symptoms above.

How To Combat Obesity With Diet Pills

If you are dangerously over weight and feel that a diet pill is your best chance of weight loss success, Phentermine is not the solution. Under no circumstances purchase this slimming drug from any online resource no matter how legitimate it may look.

An appointment to visit your GP should be made – some GP’s are pro diet pills, others are not. If your GP is pro diet pills, he or she may prescribe a course of Xenical.

Xenical is another drug classed weight loss medication and again only available via doctor prescription. Xenical is not side effect free but the possible health risks are greatly decreased. More about Xenical

If you are not considered obese or dangerously over weight you will have practically zero chance of a GP prescription.

If you wish to lose weight a natural and non-prescription diet pill offers you a high chance of weight loss success.

Read the Best Diet Pills

_________________________________________________________

Non prescription diet pills outnumber their prescription only counterparts by quite a big margin. There are several commonly prescribed diet drugs as opposed to several dozen even a couple of hundred free to buy non prescription diet pills.

Adipex is most definitely a prescription diet pill – it is a strong powerful chemically and pharmaceutically produced drug aimed at the obese and should not be entered into lightly.

Adipex is also known as Adipex-P and has an association with and contains Phentermine as an active ingredient.

How Does Adipex Work

The active ingredient of Adipex is Phentermine, as mentioned above.  Phentermine causes as reaction of the neurotransmitters in the brain. It stimulates selected nerve bundles to release chemicals that act as neurotransmitters.

Those chemicals called dopamine, epinephrine and norepinephrine—are called catecholamines. The release of these chemicals results in a lack of desire food or appetite suppression

What Are The Side Effects Of Adipex

As with a majority of prescription diet drugs – Adipex is prone to causing side effects, some serious and some a minor inconvenience.

Some minor side effects include:

• Headache or dizziness
• Insomnia and anxiety
• Diarrhea or Constipation
• Nervousness

Some of the more severe health issue that have been reoprted are:

• Chest pain or irregular heartbeat
• Breathing difficulties
• Severe migraine like headache
• Mood swings and behaviour changes
• High blood pressure
• Addiction
• Seizures

Is Adipex Suitable For Anyone

As described above, Adipex is only suitable for dieters who are considered extremely over weight or obese. It is not available on request and can only be obtained via GP or doctor consultation.

However there are certain groups who should avoid taking Adipex altogether.

Anyone with a history of heart disease or high blood pressure should refrain. Anyone with an overactive thyroid should also avoid.

If you have had a history of eye conditions such as glaucoma or blood disorders such as arteriosclerosis (artery hardening) Adipex should not be taken.

The group of people that should particularly avoid are those with an addictive nature or a history of alcohol or drug abuse.

Where To Buy Adipex

Adipex cannot be purchased it can only be acquired via GP or doctor consultation. The internet is great resource but can also be a breeding ground for the black market. It is highly advised to not attempt to buy Adipex from the internet – it is highly likely you will be buying a fraudulent product.

Alternative Diet Pills

Phentermine is possibly the most widely prescribed appetite suppressing diet drug. It was very strong and had to be administered under GP supervision.

Phen375 is derivative and contains a fat burning agent, it is manufactured in FDA approved facilities and available to buy without prescription.

More about Phen375

__________________________________________